Disrupted Meiotic cDNA1 (DMC1) Recombinase: There is Still Much to Explore

Abstract

Homologous Recombination contributes to genome integrity by repairing DNA damage accurately, and it also helps generate new genetic diversity by crossing over during meiosis. Understanding homologous recombination requires skills in biochemistry and molecular biology. Dmc1 and Rad51 recombinases are eukaryotic homologs of the Escherichia coli RecombinaseA (RecA) enzyme, which facilitates the repair of double-strand breaks in DNA by assisting homologous pairing during homologous recombination. The Dmc1 recombinase member of the RecA/Rad51 recombinase superfamily plays a vital role in meiotic recombination. DMC1 is highly conserved recombinase in eukaryotic species. Dmc1 is a meiosis-specific protein which works in ATP dependent manner. An overview of eukaryotes DMC1 recombinase is presented here concerning plant recombinase DMC1.